Amphetamine-Induced Displacement of [F] Fallypride in Striatum and Extrastriatal Regions in Humans
نویسندگان
چکیده
Patrizia Riccardi, Rui Li, Mohammad Sib Ansari, David Zald, Sohee Park, Benoit Dawant, Sharlet Anderson, Mikisha Doop, Neil Woodward, Evan Schoenberg, Dennis Schmidt, Ronald Baldwin and Robert Kessler* Department of Radiology, Vanderbilt University, Nashville, TN, USA; Department of Computer Science, Vanderbilt University, Nashville, TN, USA; Department of Psychology, Vanderbilt University, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University, Nashville, TN, USA
منابع مشابه
Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humans.
Molecular imaging has been used to estimate both drug-induced and tonic dopamine release in the striatum and most recently extrastriatal areas of healthy humans. However, to date, studies of drug-induced and tonic dopamine release have not been performed in the same subjects. This study performed positron emission tomography (PET) with [18F]fallypride in healthy subjects to assess (1) the repro...
متن کاملSex differences in amphetamine-induced displacement of [(18)F]fallypride in striatal and extrastriatal regions: a PET study.
OBJECTIVE The authors examined gender differences in d-amphetamine-induced displacements of [(18)F]fallypride in the striatal and extrastriatal brain regions and the correlations of these displacements with cognition and sensation seeking. METHOD Six women and seven men underwent positron emission tomography (PET) with [(18)F]fallypride before and after an oral dose of d-amphetamine. Percent ...
متن کاملStriatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride.
The amphetamine challenge, in which positron emission tomography (PET) or single photon emission computed tomography radioligand binding following administration of amphetamine is compared to baseline values, has been successfully used in a number of brain imaging studies as an indicator of dopaminergic function, particularly in the striatum. [(18)F] fallypride is the first PET radioligand that...
متن کاملSex Differences in Amphetamine Induced Displacement of [F] Fallypride in Striatal and Extrastriatal Regions: A PET Study
OBJECTIVE: This study examined sex differences in d-amphetamine induced displacements of [ 18 F]fallypride in striatal and extrastriatal regions and the correlations of these displacements with cognition and sensation seeking. METHOD: Six females and seven males underwent positron emission tomography with [ 18 F]fallypride before and after an oral dose of d-amphetamine. Percent displacements we...
متن کاملOptimized in vivo detection of dopamine release using 18F-fallypride PET.
UNLABELLED The high-affinity D(2/3) PET radioligand (18)F-fallypride offers the possibility of measuring both striatal and extrastriatal dopamine release during activation paradigms. When a single (18)F-fallypride scanning protocol is used, task timing is critical to the ability to explore both striatal and extrastriatal dopamine release simultaneously. We evaluated the sensitivity and optimal ...
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